主题：Frailty Mean Residual Life Regression for Clustered Survival Data
主讲人：向黎明(新加坡南洋理工大学)
主持人：刘晓玉(太阳城集团)
会议工具：腾讯会议（750-252-356）
会议时间：2022年3月2日下午15:00-16:00
摘要
Frailty models are widely used to model clustered survival data arising in multi-center clinical studies, while most of them are constructed in the context of hazard models for survival outcomes. In this talk, we introduce a frailty model framework based on mean residual life regression with random effects (frailties) to accommodate intracluster correlation and provide easy-to-understand interpretations for the effects of prognostic factors on the expected remaining lifetime of patients. A novel hierarchical quasi-likelihood approach is proposed for parameter estimation. We show favorable performance of the new proposal via simulation studies and further illustrate its application with the data from a multi-institutional study of breast cancer.
主讲人简介
向黎明，新加坡南洋理工大学副教授，于2002年获得香港城市大学统计学博士学位。研究领域为生存分析、纵向数据和聚类数据等，具体包括半参数模型，带治愈部分的区间删失数据，半竞争风险模型及高维生存数据。担任Statistics in Medicine、Computational Statistics & Data Analysis等杂志编委，已在Statistical methods in Medical Research，Statistics in Medicine、Biometrics、Journal of Multivariate Analysis、Biometrical Journal、Computational Statistics and Data Analysis 等统计学期刊上发表多篇学术论文。
